Cancer is one of the most common diseases in the world and numerous study and research are going on to make this illness curable. However, the success is till now partial. Colorectal cancer is the second most common cancers in the United States and the researchers have found a breakthrough in this.
Bacteria are dangerous for the health that probably most of us would know and understand. However, the bacteria can actually accelerate the tumor growth and cancer, the new study found. According to the study made by researchers from Israel and Harvard, the colon cancer can be drastically enhanced by the bacteria present in the mouth. It may look surprising but fusobacterium can be a catalyst to the colon cancer.
What is Fusobacteria?
Fusobacteria remains in the mouth and that is the most common place where it gets localized. These bacteria are very common in animals and are dangerous for colon cancer. Many types of research have found that the Fusobacteria are found in the colorectal tissues in human rather than the other neighboring tissues. Moreover, it gets easily localized in the mouth but not in the guts. The study showed that the enrich amount of the microbe in the colon is one of the reasons for high cancerous growth but the mechanism and process of the bacteria were still under a cloud.
How can it Accelerate Colon Cancer?
This was perhaps the mystery that scientists previously failed to understand. However, it has now been unearthed after successful research and test. The bacteria can travel through the blood and reach colon of the body. According to the study published by the Cell Host and Microbe, the researchers confirmed that apart from the localization, the bacteria carry a protein and that is called Fap2. This protein is the most dangerous aspect of the bacteria as it can bind with a sugar called Gal-GalNac and the sugar is found on the exterior surface of the colorectal tumors. As the bacteria bind with the sugar on the surface of the tumor, it strengthens it. The new combination becomes too strong that the immune system of the body fails to tackle it. In these cases, the acceleration of the tumors gets increased by a considerable amount and cancer starts spreading. According to Medical News Today, colorectal cancer can actually spread to the liver as well.
Test for Fusobacteria
The researchers carried out the practical test with mice by injecting the fusobacterium in the tail veins. There were a different combination; one was with the precancerous environment and another one with malignant colorectal tumors. In both the cases, the Fusobacteria reach the colon of the body through the bloodstream. There are samples of the human body as well that show that how effectively the Fap2 binds with the upper surface sugar of the tumor. The bacteria are no doubted more prevalent to be localized in the mouth rather than the gut and the only bloodstream can be the carrier of the fusobacterium to the colon.
How Fusobacteria can help Cancer Study
The colorectal cancer is the third leading reasons for cancer when only men or women are considered. However, it becomes the second when combined. There is obviously significant drop in the deaths caused by cancer after the medical experts found the polyps. These Colorectal Polyps can be found in the body before developing into the cancerous tumor. However, the drop is not so significant either. The Fusobacteria research can give a different dimension to the study and research. The bacteria cannot be stopped from getting into the mouth and localized there. Once it is in the mouth, then traveling to the gut is also impossible to be stopped. However, the drug can be used to stop the Fap2 protein to get bound with the Gal-GalNac sugar of the tumor. This can stop the acceleration of colorectal cancer in both men and women. However, the scope of the research is even broader. If the scientists and researchers find out the mechanism how the microbe gets localized and get attached to the colon to enhance the cancerous tumor growth, new methods can be found to curb the growth as well. As per the research, if the Fap2 protein can impair the immune system of the body, then a protein can instead weaken the tumor as well. Even though the study has just released and all the investigation and research are under nascent stage but Fusobacteria can become an opening door for colorectal cancer.
It is true that the fusobacterium is oral microbe and it can worsen the chance of survival for colorectal cancer. However, as the research gains pace, the experts believe that the microbial mechanism towards cancer can be a breakthrough in colorectal cancer treatment.