Bio Cleanse Review: Will This Supplement Really Cleanse Your Colon?

Bio Cleanse is a natural digestive health supplement which promises to cleanse your colon and improve gut health and functioning.
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For optimal digestion, many experts recommend that you combine a healthy diet and lifestyle with an organic digestive health supplement. Is Bio Cleanse a good choice for you? In this review, we’ll give you our honest opinion.

What is Bio Cleanse?

Plexus Bio Cleanse contains citrus bioflavonoids and other nutrients which promise laxative properties that cleanse the colon. This may lead to more regular bowel movements and ease symptoms like constipation and bloating.

The product also claims to destroy harmful gut microbes, improve immune function, and enhance the quality of your sleep. While some of The Plexus Bio Cleanse ingredients may help to improve digestion, there are quite a few others they could have added.

Features and Rating

Vital Reds
Editor’s Rating

Bio Cleanse


Plexus Bio Cleanse is an organic gut health supplement rich in flavonoids which aims to detox the colon and boost digestion.

You can purchase Plexus Bio Cleanse from the official site, or from select retailers. The prices on the manufacturer’s website include:


*All individuals are unique. Your results can and will vary.

  • 1 Month Supply: $46.95 Amazon
  • 3 Month Supply: $42.26 with subscription Walmart


  • Form:Capsules
  • Brand:Plexus
  • Guarantee60-Day Money Back Guarantee
  • Contact:Plexus Worldwide LLC
    9145 East Pima Center Parkway
    Scottsdale, Arizona 85258 U.S.A.
    Detailed Contact Information
  • Ingredients:Magnesium, Vitamin C, Hesperidin, Orange Peel Powder, Lemon Peel Powder, Quince Fruit Powder

How Does It Rate?

Overall Rating: 3.1

Features Rating
Ingredients 2.8/5
Value for Cost 3/5
Manufacturer 4/5
Customer Reviews 2.9/5

Pros and Cons of Bio Cleanse


  • Plexus Bio Cleanse may optimize digestion.
  • This supplement could cleanse the digestive tract.
  • Bio Cleanse Detox may support immune function.
  • It might ease symptoms like gas and bloating.
  • Bio Cleanse could destroy harmful microbes in the gut.


  • There are a number of other key ingredients they could have added.
  • The price is high for the product value.
  • Bio Cleanse may have mild side effects.

About the Brand

The manufacturer of Bio Cleanse is Plexus Worldwide LLC. Founded in 2006 as a breast health clinic, it closed and then reopened in 2008 as a general health brand.

They offer a line of natural weight loss, nutrition, digestive health, and personal care products. Plexus has their head offices in Scottsdale, Arizona.

How Does Bio Cleanse Work?

The bioflavonoids in Bio Cleanse are rich in fiber and have laxative properties. They could help move the food along the intestines to detox the colon of waste and impurities. This may promote healthier, more regular bowel movements, and reduce symptoms like diarrhea and constipation.

An article in Current Opinion in Biotechnology discussed flavonoids and their impact on the health of the gut (1).

The fiber may also help to fill the get to suppress appetite, which over time may promote some weight loss. A study on mice in the Journal of Lipid Research concluded that citrus bioflavonoids may reverse obesity and improve metabolic syndrome (2).

Bio Cleanse has some probiotic potential, which could destroy harmful intestinal bacteria. The formula contains anti-inflammatory agents which lessen gut swelling for improved digestion. They could also boost the health of other bodily organs like the heart.

Bio Cleanse has antioxidants which abolish damaging free radicals, leading to repair in the body and a potentially stronger immune system. A paper in the Journal of Physics: Conference Series examined the impact of antioxidant vitamins on the immune system (3).

What are the Key Ingredients?

Plexus Bio Cleanse Supplement Facts
Plexus Bio Cleanse Dietary Supplement Facts

These are some of the primary active Bio Cleanse ingredients:


*All individuals are unique. Your results can and will vary.

Vitamin C

This powerful antioxidant destroys free radicals and boosts overall health and immune functioning. It can repair damage to the gut as well as other parts of the body and may play a role in improving digestion.

It may also support heart health and protect from other medical conditions. A study in Foods concluded that Vitamin C was important in the oxidation and hydrolysis reactions of lipids during digestion (4).

Orange Peel Powder

Rich in bioflavonoids, orange peel may improve immunity and boost digestion. The peel is high in fiber, which helps cleanse the colon, regulate bowel movements, and ease symptoms like constipation and bloating.

It may also suppress appetite for possible weight loss benefits. A study on rats published in the Journal of Medicinal Foods found that orange peel helped regulate gastrointestinal motility (5).


This is a plant bioflavonoid high in fiber which exists in many citrus fruits. It may improve circulation, boost brain health, and improve digestion by cleansing the colon. It has some probiotic benefits which may help destroy intestinal bacteria.

It also has anti-inflammatory agents which decrease gut swelling, as well as immune-boosting antioxidants. A study in Nutrients examined the impact of hesperidin on the gut microbiota of rats and found that it had probiotic benefits (6).


Bio Cleanse contains key nutrients and bioflavonoids which have a health-boosting and laxative effect. It may cleanse the colon, repair damage, and decrease inflammation, improving digestion and decreasing constipation and other symptoms.

What Do the Bio Cleanse Reviews Say?

The Bio Cleanse Plexus reviews varied somewhat. There were a number of customers who said they got great results and would keep using it. Others were disappointed with the product, mentioning that it didn’t do as it promised.


*All individuals are unique. Your results can and will vary.

While some found the price reasonable, others said it was costly. Here are a selection of Plexus Bio Cleanse review posts, to give you an idea of the pros and cons of the brand.

No More Constipation

This product is worth every penny! No more constipation and for the first time in my life, I am ‘regular’!
– Kathleen H.

Only Worked When …

It only worked for me when I didn’t take it every day. It seemed like after a week my body adjusted to it, and I didn’t go as often. At the same time I may not have drunk enough water to push it through my system. I probably won’t buy this one again.
– Michelle Reed

It’s Okay. Not Sure If It’s Working

I don’t feel any different.
– Maria C.

Great But Expensive

Great for increasing digestive health. I use less than directed as it goes right through me, but feels great for colon health.
– Matthew T. K.

Rating for Claimed Benefits

Here is our ratings, based on scientific evidence, of how likely Bio Cleanse will be effective for its claimed benefits:

  • Promotes Regular Bowel Movements*3.0/5
  • Relieves Constipation and Other GI Symptoms*2.9/5
  • Strengthens the Immune System*4.0/5
  • Kills Harmful Gut Microbes*3.5/5

Note: We used the insights from our research and analysis to assign a star rating from one to five (five being the best; one being the worst) to this product.


Bio Cleanse is a natural digestive health supplement which promises to cleanse the colon, kill harmful gut pathogens, promote healthy bowel movements, decrease symptoms like gas and constipation, and improve sleep. It’s a quality brand, but there are other supplements for better value on the market.

Customers submitted a range of Plexus Bio Cleanse reviews, some of which were quite positive and appreciated the improvement to their general digestion and ease of symptoms. Others said it didn’t work very well, and some found it costly for the ingredients included.

Bio Cleanse Plexus contains natural ingredients, but some may cause mild symptoms. If you have side effects, stop taking supplement right away. Prior to using this product, get medical approval from a physician.

Frequently Asked Questions

Q.Plexus Bio Cleanse: When to Take?

A. The Plexus Bio Cleanse directions are 2 capsules daily with an 8 ounce glass of water. If you are following the TriPlex Weight Loss program, take 2 capsules with water twice daily in between meals.

You should also follow a low calorie diet. Do not take more than the maximum daily dosage under any circumstances.

Q.Where Can I Buy Bio Cleanse?

A. You can purchase Bio Cleanse Plexus on the manufacturer’s official site, and it’s also available from a range of other online and offline retailers like Walmart and Amazon. A one-time purchase on the official site is $46.95 per bottle.

If you join the monthly subscription service, the Plexus Bio Cleanse price for a bottle starts out at $46.95 per month and drops to $42.26 after 3 months. Customers who join the VIP program pay $34.95 per bottle.

Q.What is the Return Policy?

A. The manufacturer has a 60-day money back guarantee. Contact customer service for instructions if you want a refund and send the order back within 60 days of the purchase. You should get all of your money back, less shipping fees.

Q.What Sets It Apart From the Competition?

A. In fact, there are other richer digestive health products for the same cost, but the Bio Cleanse ingredients list is somewhat unique in that it has a very rich blend of different flavonoids.

Q.Is Plexus Bio Cleanse a Laxative?

A. The citrus bioflavonoids included in Bio Cleanse do have laxative properties which may help to cleanse and detox the colon for improved digestion.

All of the cells and tissues in your body and your major organ of detoxification, the liver rely upon your colon. The colon processes waste and bacteria preparing it for elimination from the body. Colon cleanse products should be determined based on its: potential to clean the colon of harmful waste & toxins, potential to promote better digestion & increase elimination, potential to promote improved* immune system function, potential to provide increased energy levels*. The quality of the ingredients should be backed by clinical research.

Below you'll find some of the most effective colon cleanse supplements on the market today, in our opinion.

Rating Table

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Customer Rating Great product and works with me

I tried various products with little success until I tried colon detox plus and noticed a significant change.

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**This is a subjective assessment based on the strength of the available informations and our estimation of efficacy. Colon Health Magazine adheres to strict editorial integrity standards. To the best of our knowledge, all content is accurate as of the date posted, though offers contained herein may no longer be available. The opinions expressed are the author's alone and have not been provided, approved or otherwise endorsed by our advertisers.

*Individual Results may vary. If you are pregnant, nursing, have a serious medical condition, or have a history of heart conditions we suggest consulting with a physician before using any supplement. Your health and wellness is unique to you, and the products and services we review may not be right for your circumstances. The information contained in this website is provided for educational purposes only. It is not intended to diagnose, treat, cure, or prevent any disease and should not be relied upon as a medical advice. For personal advice, please consult with a medical professional.

Disclosure of Material Connection: Some of the links in the post above are "associate sales links." This means if you can click on the link and purchase an item, we will receive a commission. Regardless, we only recommend products or services which we use personally and/or believe will add value to our readers. We are disclosing this in accordance with the Federal Trade Commission's 16 CFR, Part 255: "Guides Concerning the Use of Endorsements and Testimonials."

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